Ligand-Dependent Regiodivergent Enantioselective Allylic Alkylations of ?-Trifluoromethylated Ketones
نویسندگان
چکیده
The asymmetric introduction of the CF3 unit is a powerful tool for modifying pharmacokinetic properties and slowing metabolic degradation in medicinal chemistry. A catalytic enantioselective addition ?-CF3 enolates allows expeditious access to functionalized chiral building blocks with CF3-containing stereogenicity. computational studies reveal that choice ligand designed palladium-complex system regulates regioselectivity stereoselectivity allylic alkyation ketones Morita–Baylis–Hillman adducts.
منابع مشابه
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2021
ISSN: ['1523-7060', '1523-7052']
DOI: https://doi.org/10.1021/acs.orglett.1c00329